A single dose of the Î³-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans.

Hölttä, Mikko; Dean, Robert A; Siemers, Eric; Mawuenyega, Kwasi G; Sigurdson, Wendy; May, Patrick C; Holtzman, David M; Portelius, Erik; Zetterberg, Henrik; Bateman, Randall J; Blennow, Kaj; Gobom, Johan

Hölttä, Mikko; Dean, Robert A; Siemers, Eric; Mawuenyega, Kwasi G; Sigurdson, Wendy; May, Patrick C; Holtzman, David M; Portelius, Erik; Zetterberg, Henrik; Bateman, Randall J; Blennow, Kaj; Gobom, Johan.

Affiliation

Hölttä M; Department of Psychiatry and Neurochemistry, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SU/Mölndal Hospital, 431 80, Mölndal, Sweden. mikko_holtta@hotmail.com.
Dean RA; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Headquarters, Indianapolis, IN, 46285, USA. dean_robert_a@lilly.com.
Siemers E; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Headquarters, Indianapolis, IN, 46285, USA. siemers_eric_r@lilly.com.
Mawuenyega KG; Department of Neurology, Washington University School of Medicine, 660 South Euclid, Campus Box 8111, St. Louis, MO, 63110, USA. mawuenyegak@neuro.wustl.edu.
Sigurdson W; Department of Neurology, Washington University School of Medicine, 660 South Euclid, Campus Box 8111, St. Louis, MO, 63110, USA. sigurdsonw@neuro.wustl.edu.
May PC; Alzheimer's Disease Research Center, Washington University School of Medicine, 660 South Euclid, Campus Box 8111, St. Louis, MO, 63110, USA. sigurdsonw@neuro.wustl.edu.
Holtzman DM; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Headquarters, Indianapolis, IN, 46285, USA. may_patrick_c@lilly.com.
Portelius E; Department of Neurology, Washington University School of Medicine, 660 South Euclid, Campus Box 8111, St. Louis, MO, 63110, USA. holtzman@neuro.wustl.eduqaw.
Zetterberg H; Alzheimer's Disease Research Center, Washington University School of Medicine, 660 South Euclid, Campus Box 8111, St. Louis, MO, 63110, USA. holtzman@neuro.wustl.eduqaw.
Bateman RJ; Hope Center for Neurological Disorders, Washington University School of Medicine, 660 South Euclid, Campus Box 8111, St. Louis, MO, 63110, USA. holtzman@neuro.wustl.eduqaw.
Blennow K; Department of Psychiatry and Neurochemistry, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SU/Mölndal Hospital, 431 80, Mölndal, Sweden. erik.portelius@neuro.gu.se.
Gobom J; Department of Psychiatry and Neurochemistry, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SU/Mölndal Hospital, 431 80, Mölndal, Sweden. henrik.zetterberg@clinchem.gu.se.

Alzheimers Res Ther ; 8(1): 11, 2016 Mar 07.

Article de En | MEDLINE | ID: mdl-26948580

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Azépines / Marqueurs biologiques / Peptides bêta-amyloïdes / Précurseur de la protéine bêta-amyloïde / Alanine / Amyloid precursor protein secretases Type d'étude: Clinical_trials Limites: Humans Langue: En Journal: Alzheimers Res Ther Année: 2016 Type de document: Article Pays d'affiliation: Suède

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