Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy.
Cardiovasc Diabetol
; 15: 44, 2016 Mar 08.
Article
de En
| MEDLINE
| ID: mdl-26956801
ABSTRACT
Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes that can occur independent of hypertension or vascular disease. The underlying mechanism of DCM is incompletely understood. Some transcription factors have been suggested to regulate the gene program intricate in the pathogenesis of diabetes prompted cardiac injury. Forkhead box transcription factor 1 is a pleiotropic transcription factor that plays a pivotal role in a variety of physiological processes. Altered FOXO1 expression and function have been associated with cardiovascular diseases, and the important role of FOXO1 in DCM has begun to attract attention. In this review, we focus on the FOXO1 pathway and its role in various processes that have been related to DCM, such as metabolism, oxidative stress, endothelial dysfunction, inflammation and apoptosis.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Endothélium vasculaire
/
Transduction du signal
/
Facteurs de transcription Forkhead
/
Cardiomyopathies diabétiques
/
Myocarde
Type d'étude:
Diagnostic_studies
/
Etiology_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
Cardiovasc Diabetol
Sujet du journal:
ANGIOLOGIA
/
CARDIOLOGIA
/
ENDOCRINOLOGIA
Année:
2016
Type de document:
Article
Pays d'affiliation:
Chine