Altered isotope charge distribution of acetylcholine neurotransmitter and Myasthenia Gravis.
Med Hypotheses
; 89: 84-8, 2016 Apr.
Article
de En
| MEDLINE
| ID: mdl-26968916
ABSTRACT
Acetylcholine (ACh) is a central neurotransmitter that is used for signal transmission among neurons. For signal transmission in neurons, a neurotransmitter must bind to its receptor in order to produce an action potential. It is known that in Myasthenia Gravis (MG) cases, autoantibodies could block this binding. In the future, the treatment of MG could be achieved via modulation of molecular interaction between ACh and acetylcholine receptor (AChR). This study suggests that if an atom on a ligand (i.e. a neurotransmitter) is replaced with its isotope, it may cause charge redistribution such as that the binding between ligand and its receptor may be improved. Hence suggesting that with replacement of atoms with their isotopes in any biologically important ligand could alter its affinity towards its corresponding receptor, which would have a wide array of applications in medicine.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Acétylcholine
/
Récepteurs cholinergiques
/
Isotopes
/
Myasthénie
Langue:
En
Journal:
Med Hypotheses
Année:
2016
Type de document:
Article
Pays d'affiliation:
Turquie