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Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
Fan, Qiao; Verhoeven, Virginie J M; Wojciechowski, Robert; Barathi, Veluchamy A; Hysi, Pirro G; Guggenheim, Jeremy A; Höhn, René; Vitart, Veronique; Khawaja, Anthony P; Yamashiro, Kenji; Hosseini, S Mohsen; Lehtimäki, Terho; Lu, Yi; Haller, Toomas; Xie, Jing; Delcourt, Cécile; Pirastu, Mario; Wedenoja, Juho; Gharahkhani, Puya; Venturini, Cristina; Miyake, Masahiro; Hewitt, Alex W; Guo, Xiaobo; Mazur, Johanna; Huffman, Jenifer E; Williams, Katie M; Polasek, Ozren; Campbell, Harry; Rudan, Igor; Vatavuk, Zoran; Wilson, James F; Joshi, Peter K; McMahon, George; St Pourcain, Beate; Evans, David M; Simpson, Claire L; Schwantes-An, Tae-Hwi; Igo, Robert P; Mirshahi, Alireza; Cougnard-Gregoire, Audrey; Bellenguez, Céline; Blettner, Maria; Raitakari, Olli; Kähönen, Mika; Seppala, Ilkka; Zeller, Tanja; Meitinger, Thomas; Ried, Janina S; Gieger, Christian; Portas, Laura.
Affiliation
  • Fan Q; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
  • Verhoeven VJ; Duke-NUS Medical School, Singapore 169857, Singapore.
  • Wojciechowski R; Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
  • Barathi VA; Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
  • Hysi PG; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA.
  • Guggenheim JA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 20205, USA.
  • Höhn R; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
  • Vitart V; Duke-NUS Medical School, Singapore 169857, Singapore.
  • Khawaja AP; Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore.
  • Yamashiro K; Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, London SE1 7EH, UK.
  • Hosseini SM; School of Optometry and Vision Sciences, Cardiff University, Cardiff CF24 4HQ, UK.
  • Lehtimäki T; Department of Ophthalmology, University Medical Center Mainz, 55131 Mainz, Germany.
  • Lu Y; Department of Ophthalmology, Inselspital, University Hospital Bern, CH-3010 Bern, Switzerland.
  • Haller T; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland.
  • Xie J; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge CB2 0SR, UK.
  • Delcourt C; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
  • Pirastu M; Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto, Toronto Ontario, Canada M5G 1X8.
  • Wedenoja J; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere 33520, Finland.
  • Gharahkhani P; Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029, Australia.
  • Venturini C; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
  • Miyake M; Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria 3002, Australia.
  • Hewitt AW; Université de Bordeaux, ISPED (Institut de Santé Publique d'Épidémiologie et de Développement), Bordeaux 33000, France.
  • Guo X; INSERM, U1219-Bordeaux Population Health Research Center, Bordeaux 33000, France.
  • Mazur J; Institute of Population Genetics, National Research Council, Sassari 07100, Italy.
  • Huffman JE; Department of Public Health, University of Helsinki, Helsinki 00014, Finland.
  • Williams KM; Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland.
  • Polasek O; Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029, Australia.
  • Campbell H; Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, London SE1 7EH, UK.
  • Rudan I; UCL Institute of Ophthalmology, London SE1 7EH, UK.
  • Vatavuk Z; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
  • Wilson JF; Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria 3002, Australia.
  • Joshi PK; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania 7000, Australia.
  • McMahon G; Department of Statistical Science, School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China.
  • St Pourcain B; Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, 55131 Mainz, Germany.
  • Evans DM; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland.
  • Simpson CL; Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, London SE1 7EH, UK.
  • Schwantes-An TH; Department of Ophthalmology, King's College London, London SE1 7EH, UK.
  • Igo RP; Faculty of Medicine, University of Split, Split 21000, Croatia.
  • Mirshahi A; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.
  • Cougnard-Gregoire A; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.
  • Bellenguez C; Department of Ophthalmology, Sisters of Mercy University Hospital, Zagreb 10000, Croatia.
  • Blettner M; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.
  • Raitakari O; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.
  • Kähönen M; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol BS8 2BN, UK.
  • Seppala I; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
  • Zeller T; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol BS8 2BN, UK.
  • Meitinger T; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
  • Ried JS; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol BS8 2BN, UK.
  • Gieger C; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
  • Portas L; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia.
Nat Commun ; 7: 11008, 2016 Mar 29.
Article de En | MEDLINE | ID: mdl-27020472
ABSTRACT
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Troubles de la réfraction oculaire / Prédisposition génétique à une maladie / Niveau d&apos;instruction / Environnement / Étude d&apos;association pangénomique / Locus génétiques Type d'étude: Risk_factors_studies / Systematic_reviews Limites: Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2016 Type de document: Article Pays d'affiliation: Singapour
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Troubles de la réfraction oculaire / Prédisposition génétique à une maladie / Niveau d&apos;instruction / Environnement / Étude d&apos;association pangénomique / Locus génétiques Type d'étude: Risk_factors_studies / Systematic_reviews Limites: Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2016 Type de document: Article Pays d'affiliation: Singapour