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Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O(6)-alkylguanine-DNA alkyltransferase.
Sun, Guohui; Zhang, Na; Zhao, Lijiao; Fan, Tengjiao; Zhang, Shufen; Zhong, Rugang.
Affiliation
  • Sun G; Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, PR China.
  • Zhang N; Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, PR China.
  • Zhao L; Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, PR China. Electronic address: zhaolijiao@bjut.edu.cn.
  • Fan T; Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, PR China.
  • Zhang S; Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, PR China.
  • Zhong R; Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, PR China.
Bioorg Med Chem ; 24(9): 2097-107, 2016 May 01.
Article de En | MEDLINE | ID: mdl-27041398
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Promédicaments / O(6)-methylguanine-DNA methyltransferase / Réactifs réticulants / Antienzymes / Antinéoplasiques / Nitrosourées Limites: Humans Langue: En Journal: Bioorg Med Chem Sujet du journal: BIOQUIMICA / QUIMICA Année: 2016 Type de document: Article
Texte intégral
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Promédicaments / O(6)-methylguanine-DNA methyltransferase / Réactifs réticulants / Antienzymes / Antinéoplasiques / Nitrosourées Limites: Humans Langue: En Journal: Bioorg Med Chem Sujet du journal: BIOQUIMICA / QUIMICA Année: 2016 Type de document: Article