A Meta-Analysis of the Association between ESR1 Genetic Variants and the Risk of Breast Cancer.
PLoS One
; 11(4): e0153314, 2016.
Article
de En
| MEDLINE
| ID: mdl-27070141
ABSTRACT
BACKGROUND:
Single nucleotide polymorphisms (SNPs) in the estrogen receptor gene (ESR1) play critical roles in breast cancer (BC) susceptibility. Genome-wide association studies have reported that SNPs in ESR1 are associated with BC susceptibility; however, the results of recent studies have been inconsistent. Therefore, we performed this meta-analysis to obtain more accurate and credible results.METHODS:
We pooled published literature from PubMed, EMBASE, and Web of Science and calculated odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of associations using fixed effects models and random effects models. Twenty relevant case-control and cohort studies of the 3 related SNPs were identified.RESULTS:
Three SNPs of the ESR1 gene, rs2077647T>C, rs2228480G>A and rs3798577T>C, were not associated with increased BC risk in our overall meta-analysis. Stratified analysis by ethnicity showed that in Caucasians, the rs2228480 AA genotype was associated with a 26% decreased risk of BC compared with the GG genotype (OR = 0.740, 95% CI 0.555-0.987). The C allele of the rs3798577T>C variant was associated with decreased BC risk in Asians (OR = 0.828, 95% CI 0.730-0.939), while Caucasians with this allele were found to experience significantly increased BC risk (OR = 1.551, 95% CI 1.037-2.321). A non-significant association between rs2077647 and BC risk was identified in all of the evaluated ethnic populations.CONCLUSION:
Rs3798577 was associated with an increased risk of BC in Caucasian populations but a decreased risk in Asians. Rs2228480 had a large protective effect in Caucasians, while rs2077647 was not associated with BC risk.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Variation génétique
/
Tumeurs du sein
/
Prédisposition génétique à une maladie
/
Polymorphisme de nucléotide simple
/
Récepteur alpha des oestrogènes
Type d'étude:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limites:
Female
/
Humans
Langue:
En
Journal:
PLoS One
Sujet du journal:
CIENCIA
/
MEDICINA
Année:
2016
Type de document:
Article
Pays d'affiliation:
Chine