Hypoxia-inducible factors as molecular targets for liver diseases.
J Mol Med (Berl)
; 94(6): 613-27, 2016 06.
Article
de En
| MEDLINE
| ID: mdl-27094811
ABSTRACT
Liver disease is a growing global health problem, as deaths from end-stage liver cirrhosis and cancer are rising across the world. At present, pharmacologic approaches to effectively treat or prevent liver disease are extremely limited. Hypoxia-inducible factor (HIF) is a transcription factor that regulates diverse signaling pathways enabling adaptive cellular responses to perturbations of the tissue microenvironment. HIF activation through hypoxia-dependent and hypoxia-independent signals have been reported in liver disease of diverse etiologies, from ischemia-reperfusion-induced acute liver injury to chronic liver diseases caused by viral infection, excessive alcohol consumption, or metabolic disorders. This review summarizes the evidence for HIF stabilization in liver disease, discusses the mechanistic involvement of HIFs in disease development, and explores the potential of pharmacological HIF modifiers in the treatment of liver disease.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Carcinome hépatocellulaire
/
Facteurs de transcription à motif basique hélice-boucle-hélice
/
Sous-unité alpha du facteur-1 induit par l'hypoxie
/
Tumeurs du foie
/
Antinéoplasiques
Langue:
En
Journal:
J Mol Med (Berl)
Sujet du journal:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Année:
2016
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique