High mobility group box1 protein is involved in acute inflammation induced by Clostridium difficile toxin A.
Acta Biochim Biophys Sin (Shanghai)
; 48(6): 554-62, 2016 Jun.
Article
de En
| MEDLINE
| ID: mdl-27151296
ABSTRACT
High mobility group box1 (HMGB1), as a damage-associated inflammatory factor, contributes to the pathogenesis of numerous chronic inflammatory and autoimmune diseases. In this study, we explored the role of HMGB1 in CDI (Clostridium difficile infection) by in vivo and in vitro experiments. Our results showed that HMGB1 might play an important role in the acute inflammatory responses to C. difficile toxin A (TcdA), affect early inflammatory factors, and induce inflammation via the HMGB1-TLR4 pathway. Our study provides the essential information for better understanding the molecular mechanisms of CDI and the potential new therapeutic strategies for the treatment of this infection.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Toxines bactériennes
/
Entérocolite pseudomembraneuse
/
Protéine HMGB1
/
Entérotoxines
Type d'étude:
Etiology_studies
/
Prognostic_studies
Limites:
Animals
/
Female
/
Humans
Langue:
En
Journal:
Acta Biochim Biophys Sin (Shanghai)
Sujet du journal:
BIOFISICA
/
BIOQUIMICA
Année:
2016
Type de document:
Article
Pays d'affiliation:
Chine