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A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain.
Tabakoff, Boris; Ren, Wenhua; Vanderlinden, Lauren; Snell, Lawrence D; Matheson, Christopher J; Wang, Ze-Jun; Levinson, Rock; Smothers, C Thetford; Woodward, John J; Honse, Yumiko; Lovinger, David; Rush, Anthony M; Sather, William A; Gustafson, Daniel L; Hoffman, Paula L.
Affiliation
  • Tabakoff B; Lohocla Research Corporation, Colorado Bioscience Building, 12635 East Montview Blvd., Suite 128, Aurora, CO 80045, USA; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Campus Box: C238 12850, E. Montview
  • Ren W; Lohocla Research Corporation, Colorado Bioscience Building, 12635 East Montview Blvd., Suite 128, Aurora, CO 80045, USA. Electronic address: wenhua.ren@ucdenver.edu.
  • Vanderlinden L; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Campus Box: C238 12850, E. Montview Blvd., Aurora, CO 80045, USA. Electronic address: lauren.vanderlinden@ucdenver.edu.
  • Snell LD; Lohocla Research Corporation, Colorado Bioscience Building, 12635 East Montview Blvd., Suite 128, Aurora, CO 80045, USA. Electronic address: LDSnell56@gmail.com.
  • Matheson CJ; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Campus Box: C238 12850, E. Montview Blvd., Aurora, CO 80045, USA. Electronic address: chris.matheson@ucdenver.edu.
  • Wang ZJ; Department of Pharmacology, University of Colorado Anschutz Medical Campus, 12800 E. 19 Ave., Aurora, CO 80045 USA. Electronic address: zwang@Howard.edu.
  • Levinson R; Department of Physiology & Biophysics, University of Colorado Anschutz Medical Campus, 12800 E. 19th Ave., Aurora, CO 80045, USA. Electronic address: rock.levinson@ucdenver.edu.
  • Smothers CT; Department of Neurosciences and Department of Psychiatry, Medical University of South Carolina, 171 Ashley Ave., Charleston, SC 29425, USA. Electronic address: corigan3@aim.com.
  • Woodward JJ; Department of Neurosciences and Department of Psychiatry, Medical University of South Carolina, 171 Ashley Ave., Charleston, SC 29425, USA. Electronic address: woodward@musc.edu.
  • Honse Y; Clinical and Biological Research Unit, NIAAA, 12420 Parklawn Dr., MSC 8115, Bethesda, MD 20892-8115, USA. Electronic address: honseymk@hotmail.com.
  • Lovinger D; Clinical and Biological Research Unit, NIAAA, 12420 Parklawn Dr., MSC 8115, Bethesda, MD 20892-8115, USA. Electronic address: lovindav@mail.nih.gov.
  • Rush AM; Neurosolutions Ltd., Coventry CV4 7ZS, United Kingdom. Electronic address: tony.rush@metrionbiosciences.com.
  • Sather WA; Department of Pharmacology, University of Colorado Anschutz Medical Campus, 12800 E. 19 Ave., Aurora, CO 80045 USA. Electronic address: william.sather@ucdenver.edu.
  • Gustafson DL; UCCC Pharmacology Shared Resource, Colorado State University, Veterinary Teaching Hospital, A CC246, 300 West Drake Road, Fort Collins, CO 80023, USA. Electronic address: daniel.gustafson@ColoState.edu.
  • Hoffman PL; Department of Pharmacology, University of Colorado Anschutz Medical Campus, 12800 E. 19 Ave., Aurora, CO 80045 USA. Electronic address: paula.hoffman@ucdenver.edu.
Eur J Pharmacol ; 784: 1-14, 2016 Aug 05.
Article de En | MEDLINE | ID: mdl-27158117
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Phénylurées / Quinoléines / Récepteurs du N-méthyl-D-aspartate / Thérapie moléculaire ciblée / Canaux sodiques voltage-dépendants / Névralgie Type d'étude: Diagnostic_studies Limites: Animals / Humans / Male Langue: En Journal: Eur J Pharmacol Année: 2016 Type de document: Article Pays de publication: Pays-Bas
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Phénylurées / Quinoléines / Récepteurs du N-méthyl-D-aspartate / Thérapie moléculaire ciblée / Canaux sodiques voltage-dépendants / Névralgie Type d'étude: Diagnostic_studies Limites: Animals / Humans / Male Langue: En Journal: Eur J Pharmacol Année: 2016 Type de document: Article Pays de publication: Pays-Bas