Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells.

Oh, You-Take; Deng, Jiusheng; Yue, Ping; Sun, Shi-Yong

Oh, You-Take; Deng, Jiusheng; Yue, Ping; Sun, Shi-Yong.

Affiliation

Oh YT; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA.
Deng J; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA.
Yue P; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA.
Sun SY; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA.

Sci Rep ; 6: 26803, 2016 05 25.

Article de En | MEDLINE | ID: mdl-27222248

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sulfonamides / Régulation de l'expression des gènes tumoraux / Gènes ras / Système de signalisation des MAP kinases / Protéines proto-oncogènes B-raf / Inhibiteurs de protéines kinases / Récepteurs de TRAIL / Indoles / Protéines tumorales Limites: Humans Langue: En Journal: Sci Rep Année: 2016 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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