The preparation and characterization of PLG nanoparticles with an entrapped synthetic TLR7 agonist and their preclinical evaluation as adjuvant for an adsorbed DTaP vaccine.

Bruno, Cristina; Agnolon, Valentina; Berti, Francesco; Bufali, Simone; O'Hagan, Derek T; Baudner, Barbara C

Bruno, Cristina; Agnolon, Valentina; Berti, Francesco; Bufali, Simone; O'Hagan, Derek T; Baudner, Barbara C.

Affiliation

Bruno C; GSK Vaccines S.r.l., Via Fiorentina 1, 53100 Siena, Italy; Università di Siena, Via Aldo Moro 2, 53100 Siena, Italy. Electronic address: cristina.x.bruno@gsk.com.
Agnolon V; GSK Vaccines S.r.l., Via Fiorentina 1, 53100 Siena, Italy; Università degli Studi di Padova, Via Ugo Bassi 58b, 35121 Padova, Italy. Electronic address: va.agnolon@gmail.com.
Berti F; GSK Vaccines S.r.l., Via Fiorentina 1, 53100 Siena, Italy. Electronic address: francesco.x.berti@gsk.com.
Bufali S; GSK Vaccines S.r.l., Via Fiorentina 1, 53100 Siena, Italy. Electronic address: simone.x.bufali@gsk.com.
O'Hagan DT; GSK Vaccines, 350 Massachusetts Ave, Cambridge, 02139 MA, USA. Electronic address: derek.t.o'hagan@gsk.com.
Baudner BC; GSK Vaccines S.r.l., Via Fiorentina 1, 53100 Siena, Italy. Electronic address: barbara.c.baudner@gsk.com.

Eur J Pharm Biopharm ; 105: 1-8, 2016 Aug.

Article de En | MEDLINE | ID: mdl-27224856

Sujet(s)
Mots clés

Combination vaccines; PLG nanoparticles; Pertussis; Toll-like receptor 7 agonist; Vaccine formulation

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Acide polyglycolique / Glycoprotéines membranaires / Adjuvants immunologiques / Acide lactique / Vaccins diphtérique tétanique coquelucheux acellulaires / Récepteur de type Toll-7 / Nanoparticules Limites: Animals Langue: En Journal: Eur J Pharm Biopharm Sujet du journal: FARMACIA / FARMACOLOGIA Année: 2016 Type de document: Article

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