[A rare cause of optic neuropathy: Cassava]. / Une cause rare de neuropathie optique : le manioc.
J Fr Ophtalmol
; 39(6): 506-14, 2016 Jun.
Article
de Fr
| MEDLINE
| ID: mdl-27236340
ABSTRACT
INTRODUCTION:
Cassava root is a staple food for almost 500 million people worldwide. Excessive consumption of it is a rare cause of optic neuropathy.METHOD:
Ten patients diagnosed with cassava root related optic neuropathy were included in this retrospective study. Diagnostic criteria were a bilateral optic neuropathy preceded by significant cassava root consumption. Differential diagnoses were excluded through a neuro-ophthalmic examination, blood tests and a brain MRI. All patients had visual field examination and OCT retinal nerve fiber layer (RNFL) analysis as well as an evaluation of their cassava consumption.RESULTS:
All patients had a bilateral optic nerve head atrophy or pallor predominantly located into the temporal sector. Visual field defects consisted of a central or cecocentral scotoma for all patients. RNFL showed lower values only in the temporal sector. Mean duration of cassava consumption prior to the appearance of visual symptoms was 22.7±11.2 years with a mean of 2.57±0.53 cassava-based meals per week. Cassava related optic neuropathy is possibly due to its high cyanide content and enabled by a specific amino-acid deficiency.CONCLUSION:
Cassava root chronic consumption is a rare, underappreciated cause of optic neuropathy and its exact mechanism is still uncertain.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Troubles de la vision
/
Manihot
/
Atteintes du nerf optique
Type d'étude:
Observational_studies
/
Prognostic_studies
Limites:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
Africa
Langue:
Fr
Journal:
J Fr Ophtalmol
Année:
2016
Type de document:
Article