Neocortex expansion in development and evolution - from cell biology to single genes.
Curr Opin Neurobiol
; 39: 122-32, 2016 08.
Article
de En
| MEDLINE
| ID: mdl-27258840
ABSTRACT
Neocortex expansion in development and evolution reflects an increased and prolonged activity of neural progenitor cells. Insight into key aspects of the underlying cell biology has recently been obtained. First, the restriction of apical progenitors to undergo mitosis at the ventricular surface is overcome by generation of basal progenitors, which are free to undergo mitosis at abventricular location, typically the subventricular zone. This process involves basolateral ciliogenesis, delamination from the apical adherens junction belt, and loss of apical cell polarity. Second, proliferative capacity of basal progenitors is supported by self-produced extracellular matrix constituents, which in turn promote growth factor signalling. Humans amplify these processes by characteristic alterations in expression of key regulatory genes (PAX6), and via human-specific genes (ARHGAP11B).
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Néocortex
/
Neurones
Limites:
Humans
Langue:
En
Journal:
Curr Opin Neurobiol
Sujet du journal:
BIOLOGIA
/
NEUROLOGIA
Année:
2016
Type de document:
Article
Pays d'affiliation:
Allemagne