Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow.

Ser, Zheng; Gao, Xia; Johnson, Christelle; Mehrmohamadi, Mahya; Liu, Xiaojing; Li, Siqi; Locasale, Jason W

Ser, Zheng; Gao, Xia; Johnson, Christelle; Mehrmohamadi, Mahya; Liu, Xiaojing; Li, Siqi; Locasale, Jason W.

Affiliation

Ser Z; Tri-Institutional Training Program in Chemical Biology, Weill Cornell Medical College, Rockefeller University, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Gao X; Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA.
Johnson C; Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.
Mehrmohamadi M; Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA; Graduate Field of Genetics Genomics and Development, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 1485
Liu X; Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA.
Li S; Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA.
Locasale JW; Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: jason.locasale@duke.edu.

Cell Rep ; 15(11): 2367-76, 2016 06 14.

Article de En | MEDLINE | ID: mdl-27264180

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrimidines / Carbone / Homéostasie / Antimétabolites antinéoplasiques / Nucléotides Type d'étude: Prognostic_studies Limites: Animals Langue: En Journal: Cell Rep Année: 2016 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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