Pathogen perception by NLRs in plants and animals: Parallel worlds.
Bioessays
; 38(8): 769-81, 2016 08.
Article
de En
| MEDLINE
| ID: mdl-27339076
ABSTRACT
Intracellular NLR (Nucleotide-binding domain and Leucine-rich Repeat-containing) receptors are sensitive monitors that detect pathogen invasion of both plant and animal cells. NLRs confer recognition of diverse molecules associated with pathogen invasion. NLRs must exhibit strict intramolecular controls to avoid harmful ectopic activation in the absence of pathogens. Recent discoveries have elucidated the assembly and structure of oligomeric NLR signalling complexes in animals, and provided insights into how these complexes act as scaffolds for signal transduction. In plants, recent advances have provided novel insights into signalling-competent NLRs, and into the myriad strategies that diverse plant NLRs use to recognise pathogens. Here, we review recent insights into the NLR biology of both animals and plants. By assessing commonalities and differences between kingdoms, we are able to develop a more complete understanding of NLR function.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Plantes
/
Transduction du signal
/
Protéines NLR
/
Immunité innée
/
Infections
Limites:
Animals
Langue:
En
Journal:
Bioessays
Sujet du journal:
BIOLOGIA
/
BIOLOGIA MOLECULAR
Année:
2016
Type de document:
Article
Pays d'affiliation:
Royaume-Uni