Design and Characterization of Erwinia Chrysanthemi l-Asparaginase Variants with Diminished l-Glutaminase Activity.

Nguyen, Hien Anh; Su, Ying; Lavie, Arnon

Nguyen, Hien Anh; Su, Ying; Lavie, Arnon.

Affiliation

Nguyen HA; From the Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612 and the Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607.
Su Y; From the Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612 and the Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607.
Lavie A; From the Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612 and the Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607 Lavie@uic.edu.

J Biol Chem ; 291(34): 17664-76, 2016 08 19.

Article de En | MEDLINE | ID: mdl-27354283

Sujet(s)
Mots clés

cancer therapy; enzyme kinetics; enzyme mutation; leukemia; structural biology; structure-function; substrate specificity

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Asparaginase / Protéines bactériennes / Pectobacterium chrysanthemi / Mutation faux-sens / Glutaminase Limites: Humans Langue: En Journal: J Biol Chem Année: 2016 Type de document: Article

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