Bioactive Coumarins from the Stems of Clausena emarginata.
Chem Biodivers
; 13(9): 1178-1185, 2016 Sep.
Article
de En
| MEDLINE
| ID: mdl-27450780
ABSTRACT
Five new coumarins, clauemarmarins I - M (1 - 4), together with 10 known analogs (5 - 14), were isolated from the stems of Clausena emarginata. Compounds 8 - 13 were obtained from this plant for the first time. Their structures were established and elucidated by comprehensive analysis of spectroscopic data. The absolute configurations of 1 - 4 were further determined by their electronic circular dichroism spectroscopy. Compounds 5, 7, 12, and 14 exhibited inhibitory effects on LPS-induced NO production. Compounds 5 - 7 showed selective neuroprotective effects in Aß25 - 35 model at 10 µm.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tiges de plante
/
Neuroprotecteurs
/
Coumarines
/
Clausena
Limites:
Animals
/
Humans
Langue:
En
Journal:
Chem Biodivers
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2016
Type de document:
Article