Self-assembly modes of glycyrrhetinic acid esters in view of the crystal packing of related triterpene molecules.
Acta Crystallogr B Struct Sci Cryst Eng Mater
; 72(Pt 4): 584-92, 2016 08 01.
Article
de En
| MEDLINE
| ID: mdl-27484379
ABSTRACT
The crystal structures of three ester derivatives of glycyrrhetinic acid (GE) are reported. X-ray crystallography revealed that despite differences in the size of the ester substituents (ethyl, isopropyl and 2-morpholinoethyl) the scheme of molecular self-assembly is similar in all three cases but differs significantly from that observed in other known GE esters. According to our analysis, the two basic patterns of self-assembly of GE esters observed in their unsolvated crystals correspond to two distinct orientations of the ester groups relative to the triterpene backbone. Moreover, comparison of the self-assembly modes of GE esters in their unsolvated forms with the supramolecular organization of GE and carbenoxolone in their solvated crystals revealed that ester substituents replace solvent molecules hydrogen bonded to the COOH group at the triterpene skeleton, resulting in similar packing arrangements of these compounds.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Énoxolone
Langue:
En
Journal:
Acta Crystallogr B Struct Sci Cryst Eng Mater
Année:
2016
Type de document:
Article
Pays d'affiliation:
Pologne