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Synthetic, enzyme kinetic, and protein crystallographic studies of C-ß-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
Kantsadi, Anastassia L; Bokor, Éva; Kun, Sándor; Stravodimos, George A; Chatzileontiadou, Demetra S M; Leonidas, Demetres D; Juhász-Tóth, Éva; Szakács, Andrea; Batta, Gyula; Docsa, Tibor; Gergely, Pál; Somsák, László.
Affiliation
  • Kantsadi AL; Department of Biochemistry and Biotechnology, University of Thessaly, 26 Ploutonos Str. 41221, Larissa, Greece.
  • Bokor É; Department of Organic Chemistry, University of Debrecen, POB 400, H-4002, Debrecen, Hungary.
  • Kun S; Department of Organic Chemistry, University of Debrecen, POB 400, H-4002, Debrecen, Hungary.
  • Stravodimos GA; Department of Biochemistry and Biotechnology, University of Thessaly, 26 Ploutonos Str. 41221, Larissa, Greece.
  • Chatzileontiadou DSM; Department of Biochemistry and Biotechnology, University of Thessaly, 26 Ploutonos Str. 41221, Larissa, Greece.
  • Leonidas DD; Department of Biochemistry and Biotechnology, University of Thessaly, 26 Ploutonos Str. 41221, Larissa, Greece. Electronic address: ddleonidas@bio.uth.gr.
  • Juhász-Tóth É; Department of Organic Chemistry, University of Debrecen, POB 400, H-4002, Debrecen, Hungary.
  • Szakács A; Department of Organic Chemistry, University of Debrecen, POB 400, H-4002, Debrecen, Hungary.
  • Batta G; Department of Organic Chemistry, University of Debrecen, POB 400, H-4002, Debrecen, Hungary.
  • Docsa T; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary.
  • Gergely P; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary.
  • Somsák L; Department of Organic Chemistry, University of Debrecen, POB 400, H-4002, Debrecen, Hungary. Electronic address: somsak.laszlo@science.unideb.hu.
Eur J Med Chem ; 123: 737-745, 2016 Nov 10.
Article de En | MEDLINE | ID: mdl-27522507
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrroles / Glycogen phosphorylase / Imidazoles / Foie Limites: Animals / Humans Langue: En Journal: Eur J Med Chem Année: 2016 Type de document: Article Pays d'affiliation: Grèce Pays de publication: France
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrroles / Glycogen phosphorylase / Imidazoles / Foie Limites: Animals / Humans Langue: En Journal: Eur J Med Chem Année: 2016 Type de document: Article Pays d'affiliation: Grèce Pays de publication: France