Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices.

Wescott, Melanie P; Kufareva, Irina; Paes, Cheryl; Goodman, Jason R; Thaker, Yana; Puffer, Bridget A; Berdougo, Eli; Rucker, Joseph B; Handel, Tracy M; Doranz, Benjamin J

Wescott, Melanie P; Kufareva, Irina; Paes, Cheryl; Goodman, Jason R; Thaker, Yana; Puffer, Bridget A; Berdougo, Eli; Rucker, Joseph B; Handel, Tracy M; Doranz, Benjamin J.

Affiliation

Wescott MP; Integral Molecular, Philadelphia, PA 19104;
Kufareva I; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093.
Paes C; Integral Molecular, Philadelphia, PA 19104;
Goodman JR; Integral Molecular, Philadelphia, PA 19104;
Thaker Y; Integral Molecular, Philadelphia, PA 19104;
Puffer BA; Integral Molecular, Philadelphia, PA 19104;
Berdougo E; Integral Molecular, Philadelphia, PA 19104;
Rucker JB; Integral Molecular, Philadelphia, PA 19104;
Handel TM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093.
Doranz BJ; Integral Molecular, Philadelphia, PA 19104; bdoranz@integralmolecular.com.

Proc Natl Acad Sci U S A ; 113(35): 9928-33, 2016 08 30.

Article de En | MEDLINE | ID: mdl-27543332

Sujet(s)
Mots clés

G protein; GPCR activation; chemokine receptor; hydrophobic bridge; shotgun mutagenesis

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Conformation des protéines / Transduction du signal / Récepteurs CXCR4 Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Proc Natl Acad Sci U S A Année: 2016 Type de document: Article Pays de publication: États-Unis d'Amérique

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