The impact of 2015 neuromyelitis optica spectrum disorders criteria on diagnostic rates.
Mult Scler
; 23(2): 228-233, 2017 Feb.
Article
de En
| MEDLINE
| ID: mdl-27553618
ABSTRACT
BACKGROUND:
The international panel for neuromyelitis optica (NMO) diagnosis has proposed diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD).OBJECTIVES:
We assessed the impact of these criteria on diagnostic rates in a large cohort of patients.METHODS:
We identified and applied the 2006 and 2015 criteria to all patients ( n = 176) seen in the NMO and non-multiple sclerosis central nervous system demyelination clinic (part of the UK NMO service) from January 2013 to May 2015.RESULTS:
The 2006 criteria classified 63 of 176 (36%) patients as NMO. A total of 42 patients (67%) were aquaporin 4 (AQP4) immunoglobulin G (IgG) +ve and 21 (33%) AQP4 IgG -ve. The 2015 criteria classified 111 of 176 (63%) patients as NMOSD, of which 81 (73%) were AQP4 IgG +ve and 30 (27%) were AQP4 IgG -ve. There was an increase of 48 patients (76%) diagnosed as NMOSD using the new criteria.CONCLUSION:
Application of the 2015 criteria led to a rise in diagnosis of NMOSD by 76%. The rise in the AQP4 IgG +ve group contributed 62% and the seronegative group contributed 14%.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Autoanticorps
/
Neuromyélite optique
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
Limites:
Female
/
Humans
/
Male
Langue:
En
Journal:
Mult Scler
Sujet du journal:
NEUROLOGIA
Année:
2017
Type de document:
Article
Pays d'affiliation:
Royaume-Uni