pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.

Guo, Jianping; Chakraborty, Abhishek A; Liu, Pengda; Gan, Wenjian; Zheng, Xingnan; Inuzuka, Hiroyuki; Wang, Bin; Zhang, Jinfang; Zhang, Linli; Yuan, Min; Novak, Jesse; Cheng, Jin Q; Toker, Alex; Signoretti, Sabina; Zhang, Qing; Asara, John M; Kaelin, William G; Wei, Wenyi

Guo, Jianping; Chakraborty, Abhishek A; Liu, Pengda; Gan, Wenjian; Zheng, Xingnan; Inuzuka, Hiroyuki; Wang, Bin; Zhang, Jinfang; Zhang, Linli; Yuan, Min; Novak, Jesse; Cheng, Jin Q; Toker, Alex; Signoretti, Sabina; Zhang, Qing; Asara, John M; Kaelin, William G; Wei, Wenyi.

Affiliation

Guo J; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Chakraborty AA; Department of Medicine, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Liu P; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Gan W; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Zheng X; Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Inuzuka H; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Wang B; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Zhang J; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Zhang L; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Yuan M; Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Novak J; Department of Pathology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cheng JQ; Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Toker A; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Signoretti S; Department of Pathology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Zhang Q; Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Asara JM; Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Kaelin WG; Department of Medicine, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Wei W; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. wwei2@bidmc.harvard.edu.

Science ; 353(6302): 929-32, 2016 08 26.

Article de En | MEDLINE | ID: mdl-27563096

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Proline / Protéine Von Hippel-Lindau supresseur de tumeur / Protéines proto-oncogènes c-akt / Hypoxie tumorale / Tumeurs Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Science Année: 2016 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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