Bioenergetic Impairment in Animal and Cellular Models of Alzheimer's Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions.

Martire, Sara; Fuso, Andrea; Mosca, Luciana; Forte, Elena; Correani, Virginia; Fontana, Mario; Scarpa, Sigfrido; Maras, Bruno; d'Erme, Maria

Martire, Sara; Fuso, Andrea; Mosca, Luciana; Forte, Elena; Correani, Virginia; Fontana, Mario; Scarpa, Sigfrido; Maras, Bruno; d'Erme, Maria.

Affiliation

Martire S; Department of Biochemical Sciences, Sapienza University, Roma, Italy.
Fuso A; Department of Psychology, and European Center for Brain Research (CERC)/IRCCS Santa Lucia Foundation, Sapienza University, Roma, Italy.
Mosca L; Department of Biochemical Sciences, Sapienza University, Roma, Italy.
Forte E; Department of Biochemical Sciences, Sapienza University, Roma, Italy.
Correani V; Department of Biochemical Sciences, Sapienza University, Roma, Italy.
Fontana M; Department of Biochemical Sciences, Sapienza University, Roma, Italy.
Scarpa S; Department of Surgery "P. Valdoni", Sapienza University, Roma, Italy.
Maras B; Department of Biochemical Sciences, Sapienza University, Roma, Italy.
d'Erme M; Department of Biochemical Sciences, Sapienza University, Roma, Italy.

J Alzheimers Dis ; 54(1): 307-24, 2016 08 10.

Article de En | MEDLINE | ID: mdl-27567805

Sujet(s)
Mots clés

Alzheimer's disease; PARP-1; PKM2; bioenergetic metabolism; mitochondria

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Neuroprotecteurs / Maladie d'Alzheimer / Poly (ADP-Ribose) polymerase-1 Limites: Animals Langue: En Journal: J Alzheimers Dis Sujet du journal: GERIATRIA / NEUROLOGIA Année: 2016 Type de document: Article Pays d'affiliation: Italie Pays de publication: Pays-Bas

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