Roles of hepatocyte nuclear factors in hepatitis B virus infection.
World J Gastroenterol
; 22(31): 7017-29, 2016 Aug 21.
Article
de En
| MEDLINE
| ID: mdl-27610013
ABSTRACT
Approximately 350 million people are estimated to be persistently infected with hepatitis B virus (HBV) worldwide. HBV maintains persistent infection by employing covalently closed circular DNA (cccDNA), a template for all HBV RNAs. Chronic hepatitis B (CHB) patients are currently treated with nucleos(t)ide analogs such as lamivudine, adefovir, entecavir, and tenofovir. However, these treatments rarely cure CHB because they are unable to inhibit cccDNA transcription and inhibit only a late stage in the HBV life cycle (the reverse transcription step in the nucleocapsid). Therefore, an understanding of the factors regulating cccDNA transcription is required to stop this process. Among numerous factors, hepatocyte nuclear factors (HNFs) play the most important roles in cccDNA transcription, especially in the generation of viral genomic RNA, a template for HBV replication. Therefore, proper control of HNF function could lead to the inhibition of HBV replication. In this review, we summarize and discuss the current understanding of the roles of HNFs in the HBV life cycle and the upstream factors that regulate HNFs. This knowledge will enable the identification of new therapeutic targets to cure CHB.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Hépatite B chronique
/
Facteurs nucléaires hépatocytaires
Type d'étude:
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
World J Gastroenterol
Sujet du journal:
GASTROENTEROLOGIA
Année:
2016
Type de document:
Article
Pays d'affiliation:
Corée du Sud