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An enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and Its potential anticancer application.
Chou, Feng-Pai; Tsai, Chia-Tse; Chiou, Ya-Sheng; Chen, Yi-Ju; Li, Meng-Erh; Guo, Ting-Wei; Lyu, Jason WenJay; Chou, Sheng-Hao; Wu, Tung-Kung.
Affiliation
  • Chou FP; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, R.O.C.
  • Tsai CT; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, R.O.C.
  • Chiou YS; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, R.O.C.
  • Chen YJ; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, R.O.C.
  • Li ME; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, R.O.C.
  • Guo TW; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, R.O.C.
  • Lyu JW; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, R.O.C.
  • Chou SH; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, R.O.C.
  • Wu TK; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, R.O.C.
Chem Biol Drug Des ; 89(1): 61-66, 2017 Jan.
Article de En | MEDLINE | ID: mdl-27647631
ABSTRACT
Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Glucosides / Androstérone / Antinéoplasiques Langue: En Journal: Chem Biol Drug Des Sujet du journal: BIOQUIMICA / FARMACIA / FARMACOLOGIA Année: 2017 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Glucosides / Androstérone / Antinéoplasiques Langue: En Journal: Chem Biol Drug Des Sujet du journal: BIOQUIMICA / FARMACIA / FARMACOLOGIA Année: 2017 Type de document: Article