In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas.
Antimicrob Agents Chemother
; 60(12): 7502-7504, 2016 12.
Article
de En
| MEDLINE
| ID: mdl-27671057
ABSTRACT
In vitro activities of omadacycline, a new aminomethylcycline, were determined for Mycoplasma and Ureaplasma spp. and compared with those of azithromycin, clindamycin, moxifloxacin, tetracycline, and doxycycline. All omadacycline MICs were <2 µg/ml. MIC90s were 0.063 µg/ml for Mycoplasma hominis, 0.25 µg/ml for Mycoplasma pneumoniae, and 2 µg/ml for Ureaplasma spp. Omadacycline had the lowest MIC90 among all drugs tested against M. hominis Omadacycline activity was not affected by macrolide, tetracycline, or fluoroquinolone resistance.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tétracyclines
/
Mycoplasma hominis
/
Antibactériens
/
Mycoplasma pneumoniae
Limites:
Humans
Pays/Région comme sujet:
America do norte
/
Asia
Langue:
En
Journal:
Antimicrob Agents Chemother
Année:
2016
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique