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Functional 1,3a,6a-triazapentalene scaffold: Design of fluorescent probes for kinesin spindle protein (KSP).
Sawada, Jun-Ichi; Osawa, Ayumi; Takeuchi, Tomoki; Kaneda, Masato; Oishi, Shinya; Fujii, Nobutaka; Asai, Akira; Tanino, Keiji; Namba, Kosuke.
Affiliation
  • Sawada JI; Graduate School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, Japan.
  • Osawa A; Graduate School of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Kita-ku, Sapporo 060-0810, Japan.
  • Takeuchi T; Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
  • Kaneda M; Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
  • Oishi S; Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address: soishi@pharm.kyoto-u.ac.jp.
  • Fujii N; Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
  • Asai A; Graduate School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address: aasai@u-shizuoka-ken.ac.jp.
  • Tanino K; Department of Chemistry, Faculty of Science, Hokkaido University, Kita-ku, Sapporo 060-0810, Japan.
  • Namba K; Graduate School of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan; Department of Chemistry, Faculty of Science, Hokkaido University, Kita-ku, Sapporo 060-0810, Japan.
Bioorg Med Chem Lett ; 26(23): 5765-5769, 2016 12 01.
Article de En | MEDLINE | ID: mdl-27793568
ABSTRACT
1,3a,6a-Triazapentalene is a compact fluorescent chromophore. In this study, triazapentalene was used to modify a series of biphenyl-type inhibitors of kinesin spindle protein (KSP) to develop fluorescent probes for the intracellular visualization of this protein. Microscopic studies demonstrated that these novel triazapentalene-labeled compounds exhibited inhibitory activity towards KSP in cultured cells and provided important information concerning the intracellular distribution.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Kinésine / Composés hétérocycliques bicycliques / Colorants fluorescents Limites: Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2016 Type de document: Article Pays d'affiliation: Japon
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Kinésine / Composés hétérocycliques bicycliques / Colorants fluorescents Limites: Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2016 Type de document: Article Pays d'affiliation: Japon