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Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.
Dressman, Bruce A; Tromiczak, Eric G; Chappell, Mark D; Tripp, Allie E; Quimby, Steven J; Vetman, Tatiana; Fivush, Adam M; Matt, James; Jaramillo, Carlos; Li, Renhua; Khilevich, Albert; Blanco, Maria-Jesus; Smith, Stephon C; Carpintero, Mercedes; de Diego, José Eugenio; Barberis, Mario; García-Cerrada, Susana; Soriano, José F; Schkeryantz, Jeffrey M; Witkin, Jeffrey M; Wafford, Keith A; Seidel, Wesley; Britton, Thomas; Overshiner, Carl D; Li, Xia; Wang, Xu-Shan; Heinz, Beverly A; Catlow, John T; Swanson, Steven; Bedwell, David; Ornstein, Paul L; Mitch, Charles H.
Affiliation
  • Dressman BA; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA. Electronic address: DRESSMAN_BRUCE_A@lilly.com.
  • Tromiczak EG; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Chappell MD; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Tripp AE; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Quimby SJ; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Vetman T; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Fivush AM; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Matt J; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Jaramillo C; Avenida de la Industria, 30, 28108 Alcobendas, Madrid, Spain.
  • Li R; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Khilevich A; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Blanco MJ; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Smith SC; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Carpintero M; Avenida de la Industria, 30, 28108 Alcobendas, Madrid, Spain.
  • de Diego JE; Avenida de la Industria, 30, 28108 Alcobendas, Madrid, Spain.
  • Barberis M; Avenida de la Industria, 30, 28108 Alcobendas, Madrid, Spain.
  • García-Cerrada S; Avenida de la Industria, 30, 28108 Alcobendas, Madrid, Spain.
  • Soriano JF; Avenida de la Industria, 30, 28108 Alcobendas, Madrid, Spain.
  • Schkeryantz JM; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Witkin JM; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Wafford KA; Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK.
  • Seidel W; Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK.
  • Britton T; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Overshiner CD; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Li X; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Wang XS; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Heinz BA; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Catlow JT; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Swanson S; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Bedwell D; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Ornstein PL; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
  • Mitch CH; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.
Bioorg Med Chem Lett ; 26(23): 5663-5668, 2016 12 01.
Article de En | MEDLINE | ID: mdl-27836401
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Récepteurs métabotropes au glutamate / Acide glutamique / Trouble dépressif majeur / Antidépresseurs Limites: Animals / Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2016 Type de document: Article Pays de publication: Royaume-Uni
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Récepteurs métabotropes au glutamate / Acide glutamique / Trouble dépressif majeur / Antidépresseurs Limites: Animals / Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2016 Type de document: Article Pays de publication: Royaume-Uni