Persistent Impairment of Quality of Life in Patients with Herpes Simplex Keratitis.
Ophthalmology
; 124(2): 160-169, 2017 02.
Article
de En
| MEDLINE
| ID: mdl-27863844
ABSTRACT
PURPOSE:
To evaluate the quality of life (QoL) in patients with quiescent herpes simplex keratitis compared with control patients without ocular herpes.DESIGN:
Prospective, case-control study.PARTICIPANTS:
Thirty-three patients with a unilateral and relapsing herpes simplex keratitis (HSK group) that was quiescent during evaluation (no acute episode in the past 3 months) and 66 patients with no history of HSK (control group). Both groups were age and gender matched.METHODS:
Three previously validated QoL questionnaires were used in this study the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25), Glaucoma Quality of Life 17 (Glau-QoL17) questionnaire, and Ocular Surface Disease Quality of Life (OSD-QoL) questionnaire. Each questionnaire covered various aspects of the disease. MAIN OUTCOMEMEASURES:
The outcomes of the 3 questionnaires were compared between groups. For the HSK group, the results were correlated to the clinical findings and the history of herpetic disease.RESULTS:
The mean total questionnaire scores of the 3 QoL questionnaires were significantly lower in the HSK group compared with controls (NEI VFQ-25 70.5±3.8 vs. 91.1±0.8, P < 0.0001; Glau-QoL17 68.2±3.1 vs. 87.9±1.0, P < 0.0001; and OSD-QoL 65.4±2.9 vs. 93.1±0.6, P < 0.0001, respectively). In the HSK group, the level of visual acuity (VA) in the affected eye had the greatest impact on QoL, inducing lower QoL results related to "general vision," "distance activities," "dependency," "peripheral vision," "self-image," "daily living," and "driving" dimensions. Decreased VA in the unaffected eye also negatively affected "self-image" and "driving" results. Patients with frequent HSK relapses had lower QoL related to "ocular pain" and "acknowledgement."CONCLUSIONS:
Even during a quiescent phase of the disease, unilateral and relapsing HSK significantly impairs the QoL of patients to a similar level as most sight-threatening diseases. The decrease of VA has the greatest overall effect, but other factors also significantly affect QoL, such as the frequency of relapses.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Qualité de vie
/
Troubles de la vision
/
Kératite herpétique
Type d'étude:
Observational_studies
/
Qualitative_research
/
Risk_factors_studies
Aspects:
Patient_preference
Limites:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
America do norte
Langue:
En
Journal:
Ophthalmology
Année:
2017
Type de document:
Article
Pays d'affiliation:
France