Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson's disease.

Yeung, Patrick K K; Lai, Angela K W; Son, Hyo Jin; Zhang, Xu; Hwang, Onyou; Chung, Stephen S M; Chung, Sookja K

Yeung, Patrick K K; Lai, Angela K W; Son, Hyo Jin; Zhang, Xu; Hwang, Onyou; Chung, Stephen S M; Chung, Sookja K.

Affiliation

Yeung PKK; School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China.
Lai AKW; School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China.
Son HJ; Department of Biochemistry, University of Ulsan College of Medicine, Seoul, Korea.
Zhang X; School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China.
Hwang O; Department of Biochemistry, University of Ulsan College of Medicine, Seoul, Korea.
Chung SSM; Division of Science and Technology, United International College, Zhuhai, Guandong, China.
Chung SK; School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China; Research Center of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address: skchung@hkucc.hku.hk.

Neurobiol Aging ; 50: 119-133, 2017 02.

Article de En | MEDLINE | ID: mdl-27960106

Sujet(s)
Mots clés

Aldose reductase; Knockout mice; Oxidative stress; Parkinson's disease

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie de Parkinson / Autophagie / Aldose reductase / Stress oxydatif / Neurones dopaminergiques Type d'étude: Prognostic_studies Limites: Animals Langue: En Journal: Neurobiol Aging Année: 2017 Type de document: Article Pays d'affiliation: Chine Pays de publication: États-Unis d'Amérique

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