Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science
; 354(6319): 1543, 2016 12 23.
Article
de En
| MEDLINE
| ID: mdl-28008037
ABSTRACT
Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Histone
/
Complexe répresseur Polycomb-2
Langue:
En
Journal:
Science
Année:
2016
Type de document:
Article
Pays d'affiliation:
Royaume-Uni