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Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment.
Hroch, Lukas; Guest, Patrick; Benek, Ondrej; Soukup, Ondrej; Janockova, Jana; Dolezal, Rafael; Kuca, Kamil; Aitken, Laura; Smith, Terry K; Gunn-Moore, Frank; Zala, Dominykas; Ramsay, Rona R; Musilek, Kamil.
Affiliation
  • Hroch L; Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Department of Pharmaceutical Chemistry and Drug Control, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic; University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
  • Guest P; University of St. Andrews, School of Biology, Medical and Biological Sciences Building or Biomedical Sciences Research Complex, North Haugh, St. Andrews KY16 9ST, United Kingdom.
  • Benek O; University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic; University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
  • Soukup O; University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
  • Janockova J; University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
  • Dolezal R; University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic; University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic; University of Hradec Kralove, Faculty of Informatics and Management
  • Kuca K; University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic; University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
  • Aitken L; University of St. Andrews, School of Biology, Medical and Biological Sciences Building or Biomedical Sciences Research Complex, North Haugh, St. Andrews KY16 9ST, United Kingdom.
  • Smith TK; University of St. Andrews, School of Biology, Medical and Biological Sciences Building or Biomedical Sciences Research Complex, North Haugh, St. Andrews KY16 9ST, United Kingdom.
  • Gunn-Moore F; University of St. Andrews, School of Biology, Medical and Biological Sciences Building or Biomedical Sciences Research Complex, North Haugh, St. Andrews KY16 9ST, United Kingdom.
  • Zala D; University of St. Andrews, School of Biology, Medical and Biological Sciences Building or Biomedical Sciences Research Complex, North Haugh, St. Andrews KY16 9ST, United Kingdom.
  • Ramsay RR; University of St. Andrews, School of Biology, Medical and Biological Sciences Building or Biomedical Sciences Research Complex, North Haugh, St. Andrews KY16 9ST, United Kingdom.
  • Musilek K; University Hospital, Biomedical Research Center, Sokolska 581, 500 05 Hradec Kralove, Czech Republic; University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic. Electronic address: kamil.musilek@gmail.com.
Bioorg Med Chem ; 25(3): 1143-1152, 2017 02 01.
Article de En | MEDLINE | ID: mdl-28082069

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Phénylurées / Thiourée / Antienzymes / Benzothiazoles / Maladie d'Alzheimer / 3-Hydroxyacyl-CoA dehydrogenases / Monoamine oxidase Limites: Humans Langue: En Journal: Bioorg Med Chem Sujet du journal: BIOQUIMICA / QUIMICA Année: 2017 Type de document: Article Pays d'affiliation: République tchèque Pays de publication: Royaume-Uni

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Phénylurées / Thiourée / Antienzymes / Benzothiazoles / Maladie d'Alzheimer / 3-Hydroxyacyl-CoA dehydrogenases / Monoamine oxidase Limites: Humans Langue: En Journal: Bioorg Med Chem Sujet du journal: BIOQUIMICA / QUIMICA Année: 2017 Type de document: Article Pays d'affiliation: République tchèque Pays de publication: Royaume-Uni