Msi1 promotes tumor progression by epithelial-to-mesenchymal transition in cervical cancer.
Hum Pathol
; 65: 53-61, 2017 07.
Article
de En
| MEDLINE
| ID: mdl-28088346
ABSTRACT
Musashi1 (Msi1) is an RNA-binding protein that has been reported to be a pivotal regulator in tumorigenesis and progression in several cancers. However, its function and mechanism in cervical cancer is still unknown. In this study, Msi1 expression was found elevated in cervical cancers by immunohistochemistry and correlated with poor outcomes. Then, endogenous Msi1 was silenced in cervical cancer cell lines by short hairpin RNA, and its function and mechanism were determined. The results showed that the silencing of Msi1 in SiHa and HeLa cells inhibited the cells' migratory and invasive abilities in vitro and tumor progression in vivo. Epithelial-to-mesenchymal transition (EMT) markers were down-regulated, and Wnt activity was inhibited by the silencing of Msi1. In clinical tissues, positive correlations between Msi1 and EMT markers were found. In conclusion, Msi1, a diagnostic marker and potential therapeutic target, promoted the EMT progression through activation of the Wnt signaling pathway in cervical cancers, thereby contributing to poor prognosis.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Marqueurs biologiques tumoraux
/
Tumeurs du col de l'utérus
/
Protéines de liaison à l'ARN
/
Transition épithélio-mésenchymateuse
/
Protéines de tissu nerveux
Type d'étude:
Prognostic_studies
Limites:
Animals
/
Female
/
Humans
/
Middle aged
Langue:
En
Journal:
Hum Pathol
Sujet du journal:
PATOLOGIA
Année:
2017
Type de document:
Article
Pays d'affiliation:
Chine