Association of Osteopontin Gene Polymorphisms with Colorectal Cancer.
Cancer Invest
; 35(2): 71-77, 2017 Feb 07.
Article
de En
| MEDLINE
| ID: mdl-28095066
ABSTRACT
We investigated the association of the Osteopontin (OPN) (rs9138 and rs1126616) polymorphisms with colorectal cancer (CRC). One hundred CRC patients and 112 healthy individuals were subjected to OPN (rs9138 and rs1126616) genotyping and measurement of OPN protein plasma level. The C allele of OPN rs1126616 and the CC haplotype were significantly higher in CRC patient (p = 0.036, 0.003, respectively). In females, the C allele of OPN rs9318 (A/C) polymorphism was significantly associated with increased CRC risk (p = 0.036). The plasma OPN level >104.35 ng/mL was significantly associated with CRC. Our findings suggest a significant role played by OPN (rs9138 and rs1126616) in colorectal carcinogenesis.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs colorectales
/
Ostéopontine
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites:
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Cancer Invest
Année:
2017
Type de document:
Article
Pays d'affiliation:
Égypte