Global and regional dissemination and evolution of Burkholderia pseudomallei.
Nat Microbiol
; 2: 16263, 2017 Jan 23.
Article
de En
| MEDLINE
| ID: mdl-28112723
ABSTRACT
The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Burkholderia pseudomallei
/
Évolution moléculaire
/
Mélioïdose
Limites:
Animals
/
Humans
Pays/Région comme sujet:
Asia
/
Oceania
Langue:
En
Journal:
Nat Microbiol
Année:
2017
Type de document:
Article
Pays d'affiliation:
Royaume-Uni