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The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation.
Dahl, Jan-Ulrik; Gray, Michael J; Bazopoulou, Daphne; Beaufay, Francois; Lempart, Justine; Koenigsknecht, Mark J; Wang, Ying; Baker, Jason R; Hasler, William L; Young, Vincent B; Sun, Duxin; Jakob, Ursula.
Affiliation
  • Dahl JU; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Gray MJ; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Bazopoulou D; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Beaufay F; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Lempart J; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Koenigsknecht MJ; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Wang Y; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Baker JR; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Hasler WL; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Young VB; Department of Internal Medicine/Division of Infectious Diseases &Department of Microbiology and Immunology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Sun D; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Jakob U; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Nat Microbiol ; 2: 16267, 2017 Jan 23.
Article de En | MEDLINE | ID: mdl-28112760
ABSTRACT
Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria towards oxidative stress, reduces colonization and attenuates persister cell and biofilm formation, suggesting that mesalamine aids in diminishing the capacity of bacteria to persist within chronically inflamed environments.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Polyphosphates / Anti-inflammatoires non stéroïdiens / Mésalazine / Microbiome gastro-intestinal / Bactéries à Gram négatif Limites: Animals / Humans Langue: En Journal: Nat Microbiol Année: 2017 Type de document: Article Pays d'affiliation: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Polyphosphates / Anti-inflammatoires non stéroïdiens / Mésalazine / Microbiome gastro-intestinal / Bactéries à Gram négatif Limites: Animals / Humans Langue: En Journal: Nat Microbiol Année: 2017 Type de document: Article Pays d'affiliation: États-Unis d'Amérique