MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.

Prange, K H M; Mandoli, A; Kuznetsova, T; Wang, S-Y; Sotoca, A M; Marneth, A E; van der Reijden, B A; Stunnenberg, H G; Martens, J H A

Prange, K H M; Mandoli, A; Kuznetsova, T; Wang, S-Y; Sotoca, A M; Marneth, A E; van der Reijden, B A; Stunnenberg, H G; Martens, J H A.

Affiliation

Prange KHM; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.
Mandoli A; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.
Kuznetsova T; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.
Wang SY; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.
Sotoca AM; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.
Marneth AE; Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
van der Reijden BA; Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Stunnenberg HG; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.
Martens JHA; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.

Oncogene ; 36(23): 3346-3356, 2017 06 08.

Article de En | MEDLINE | ID: mdl-28114278

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Chromosomes humains de la paire 11 / Leucémie aigüe myéloïde / Régulation de l'expression des gènes tumoraux / Protéines de fusion oncogènes / Éléments activateurs (génétique) / Protéine de la leucémie myéloïde-lymphoïde / Sous-unité alpha 2 du facteur CBF Type d'étude: Prognostic_studies Limites: Adult / Female / Humans / Infant / Male / Middle aged Langue: En Journal: Oncogene Sujet du journal: BIOLOGIA MOLECULAR / NEOPLASIAS Année: 2017 Type de document: Article Pays d'affiliation: Pays-Bas Pays de publication: Royaume-Uni

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