AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells.

Min, Ahrum; Im, Seock-Ah; Jang, Hyemin; Kim, Seongyeong; Lee, Miso; Kim, Debora Keunyoung; Yang, Yaewon; Kim, Hee-Jun; Lee, Kyung-Hun; Kim, Jin Won; Kim, Tae-Yong; Oh, Do-Youn; Brown, Jeff; Lau, Alan; O'Connor, Mark J; Bang, Yung-Jue

Min, Ahrum; Im, Seock-Ah; Jang, Hyemin; Kim, Seongyeong; Lee, Miso; Kim, Debora Keunyoung; Yang, Yaewon; Kim, Hee-Jun; Lee, Kyung-Hun; Kim, Jin Won; Kim, Tae-Yong; Oh, Do-Youn; Brown, Jeff; Lau, Alan; O'Connor, Mark J; Bang, Yung-Jue.

Affiliation

Min A; Cancer Research Institute, Seoul National University, Seoul, Korea.
Im SA; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
Jang H; Cancer Research Institute, Seoul National University, Seoul, Korea. moisa@snu.ac.kr.
Kim S; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
Lee M; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Kim DK; Cancer Research Institute, Seoul National University, Seoul, Korea.
Yang Y; Cancer Research Institute, Seoul National University, Seoul, Korea.
Kim HJ; Cancer Research Institute, Seoul National University, Seoul, Korea.
Lee KH; Rice University, Houston, Texas.
Kim JW; Cancer Research Institute, Seoul National University, Seoul, Korea.
Kim TY; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Oh DY; Cancer Research Institute, Seoul National University, Seoul, Korea.
Brown J; Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea.
Lau A; Cancer Research Institute, Seoul National University, Seoul, Korea.
O'Connor MJ; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
Bang YJ; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Mol Cancer Ther ; 16(4): 566-577, 2017 04.

Article de En | MEDLINE | ID: mdl-28138034

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrimidines / Tumeurs de l'estomac / Sulfoxydes / Points de contrôle du cycle cellulaire / Protéines mutées dans l'ataxie-télangiectasie / Mutations synthétiques létales Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Mol Cancer Ther Sujet du journal: ANTINEOPLASICOS Année: 2017 Type de document: Article

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