Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction.
J Clin Invest
; 127(3): 899-911, 2017 Mar 01.
Article
de En
| MEDLINE
| ID: mdl-28165342
ABSTRACT
Ischemic heart disease resulting from myocardial infarction (MI) is the most prevalent form of heart disease in the United States. Post-MI cardiac remodeling is a multifaceted process that includes activation of fibroblasts and a complex immune response. T-regulatory cells (Tregs), a subset of CD4+ T cells, have been shown to suppress the innate and adaptive immune response and limit deleterious remodeling following myocardial injury. However, the mechanisms by which injured myocardium recruits suppressive immune cells remain largely unknown. Here, we have shown a role for Hippo signaling in the epicardium in suppressing the post-infarct inflammatory response through recruitment of Tregs. Mice deficient in epicardial YAP and TAZ, two core Hippo pathway effectors, developed profound post-MI pericardial inflammation and myocardial fibrosis, resulting in cardiomyopathy and death. Mutant mice exhibited fewer suppressive Tregs in the injured myocardium and decreased expression of the gene encoding IFN-γ, a known Treg inducer. Furthermore, controlled local delivery of IFN-γ following MI rescued Treg infiltration into the injured myocardium of YAP/TAZ mutants and decreased fibrosis. Collectively, these results suggest that epicardial Hippo signaling plays a key role in adaptive immune regulation during the post-MI recovery phase.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Péricarde
/
Phosphoprotéines
/
Facteurs de transcription
/
Lymphocytes T régulateurs
/
Protéines adaptatrices de la transduction du signal
/
Tolérance immunitaire
/
Infarctus du myocarde
Type d'étude:
Etiology_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
J Clin Invest
Année:
2017
Type de document:
Article