A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear.

Landegger, Lukas D; Pan, Bifeng; Askew, Charles; Wassmer, Sarah J; Gluck, Sarah D; Galvin, Alice; Taylor, Ruth; Forge, Andrew; Stankovic, Konstantina M; Holt, Jeffrey R; Vandenberghe, Luk H

Landegger, Lukas D; Pan, Bifeng; Askew, Charles; Wassmer, Sarah J; Gluck, Sarah D; Galvin, Alice; Taylor, Ruth; Forge, Andrew; Stankovic, Konstantina M; Holt, Jeffrey R; Vandenberghe, Luk H.

Affiliation

Landegger LD; Eaton Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear, Boston, Massachusetts, USA.
Pan B; Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.
Askew C; Department of Otolaryngology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
Wassmer SJ; Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.
Gluck SD; Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.
Galvin A; Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.
Taylor R; Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.
Forge A; Grousbeck Gene Therapy Center, Schepens Eye Research Institute and Massachusetts Eye and Ear, Boston, Massachusetts, USA.
Stankovic KM; Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Holt JR; Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.
Vandenberghe LH; Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.

Nat Biotechnol ; 35(3): 280-284, 2017 03.

Article de En | MEDLINE | ID: mdl-28165475

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Plasmides / Transduction génétique / Thérapie génétique / Cochlée / Dependovirus / Vecteurs génétiques Limites: Animals Langue: En Journal: Nat Biotechnol Sujet du journal: BIOTECNOLOGIA Année: 2017 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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