A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway.

Xu, Shengtao; Yao, Hong; Luo, Shanshan; Zhang, Yun-Kai; Yang, Dong-Hua; Li, Dahong; Wang, Guangyu; Hu, Mei; Qiu, Yangyi; Wu, Xiaoming; Yao, Hequan; Xie, Weijia; Chen, Zhe-Sheng; Xu, Jinyi

Xu, Shengtao; Yao, Hong; Luo, Shanshan; Zhang, Yun-Kai; Yang, Dong-Hua; Li, Dahong; Wang, Guangyu; Hu, Mei; Qiu, Yangyi; Wu, Xiaoming; Yao, Hequan; Xie, Weijia; Chen, Zhe-Sheng; Xu, Jinyi.

Affiliation

Xu S; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Yao H; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Luo S; Department of Pharmacology, School of Pharmacy, Fudan University , Shanghai 201203, P. R. China.
Zhang YK; College of Pharmacy and Health Sciences, St. John's University , 8000 Utopia Parkway, Queens, New York 11439, United States.
Yang DH; College of Pharmacy and Health Sciences, St. John's University , 8000 Utopia Parkway, Queens, New York 11439, United States.
Li D; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Wang G; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , 103 Wen Hua Road, Shenyang 110016, China.
Hu M; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Qiu Y; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Wu X; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Yao H; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Xie W; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Chen ZS; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Xu J; College of Pharmacy and Health Sciences, St. John's University , 8000 Utopia Parkway, Queens, New York 11439, United States.

J Med Chem ; 60(4): 1449-1468, 2017 02 23.

Article de En | MEDLINE | ID: mdl-28165738

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Région mammaire / Tumeurs du sein / Apoptose / Diterpènes de type kaurane / Antinéoplasiques Limites: Animals / Female / Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2017 Type de document: Article

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