Glutathione system participation in thoracic aneurysms from patients with Marfan syndrome.
Vasa
; 46(3): 177-186, 2017 May.
Article
de En
| MEDLINE
| ID: mdl-28173744
ABSTRACT
BACKGROUND:
Aortic dilatation in Marfan syndrome (MFS) is progressive. It is associated with oxidative stress and endothelial dysfunction that contribute to the early acute dissection of the vessel and can result in rupture of the aorta and sudden death. We evaluated the participation of the glutathione (GSH) system, which could be involved in the mechanisms that promote the formation and progression of the aortic aneurysms in MFS patients. PATIENTS ANDMETHODS:
Aortic aneurysm tissue was obtained during chest surgery from eight control subjects and 14 MFS patients. Spectrophotometrical determination of activity of glutathione peroxidase (GPx), glutathione-S-transferase (GST), glutathione reductase (GR), lipid peroxidation (LPO) index, carbonylation, total antioxidant capacity (TAC), and concentration of reduced and oxidized glutathione (GSH and GSSG respectively), was performed in the homogenate from aortic aneurysm tissue.RESULTS:
LPO index, carbonylation, TGF-ß1, and GR activity were increased in MFS patients (p < 0.04), while TAC, GSH/GSSG ratio, GPx, and GST activity were significantly decreased (p < 0.04).CONCLUSIONS:
The depletion of GSH, in spite of the elevated activity of GR, not only diminished the activity of GSH-depend GST and GPx, but increased LPO, carbonylation and decreased TAC. These changes could promote the structural and functional alterations in the thoracic aorta of MFS patients.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Aorte thoracique
/
Anévrysme de l'aorte thoracique
/
Stress oxydatif
/
Glutathion
/
Syndrome de Marfan
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limites:
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Vasa
Année:
2017
Type de document:
Article