Histone deacetylase inhibitor MS-275 augments expression of a subset of IFN-Î³-regulated genes in Toxoplasma gondii-infected macrophages but does not improve parasite control.

Sumpf, Kristina; Nast, Roswitha; Downie, Bryan; Salinas, Gabriela; Lüder, Carsten G K

Sumpf, Kristina; Nast, Roswitha; Downie, Bryan; Salinas, Gabriela; Lüder, Carsten G K.

Affiliation

Sumpf K; Institute for Medical Microbiology, University Medical Center, Georg-August-University, Kreuzbergring 57, 37075 Göttingen, Germany.
Nast R; Institute for Medical Microbiology, University Medical Center, Georg-August-University, Kreuzbergring 57, 37075 Göttingen, Germany.
Downie B; Transcriptome and Genome Analysis Laboratory, University Medical Center, Georg-August-University, Justus-von-Liebig-Weg 11, 37077 Göttingen, Germany.
Salinas G; Transcriptome and Genome Analysis Laboratory, University Medical Center, Georg-August-University, Justus-von-Liebig-Weg 11, 37077 Göttingen, Germany.
Lüder CGK; Institute for Medical Microbiology, University Medical Center, Georg-August-University, Kreuzbergring 57, 37075 Göttingen, Germany. Electronic address: clueder@gwdg.de.

Exp Parasitol ; 180: 45-54, 2017 Sep.

Article de En | MEDLINE | ID: mdl-28189488

Sujet(s)
Mots clés

Histone deacetylase; Immune evasion; Interferon-gamma; MS-275; Supportive therapy; Toxoplasma gondii

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyridines / Toxoplasma / Benzamides / Expression des gènes / Interféron gamma / Inhibiteurs de désacétylase d'histone / Macrophages Limites: Animals Langue: En Journal: Exp Parasitol Année: 2017 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: États-Unis d'Amérique

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