Outcomes of transoral laser microsurgical management of T1b stage glottic cancer.
J Laryngol Otol
; 131(5): 433-441, 2017 May.
Article
de En
| MEDLINE
| ID: mdl-28193302
ABSTRACT
OBJECTIVE:
This study aimed to evaluate the oncological and voice outcomes of transoral laser microsurgery for tumour stage T1b stage glottic cancer patients.METHODS:
A prospective cohort study in a tertiary care head and neck cancer centre included tumour-node-metastasis stage T1bN0M0 glottic cancer patients scheduled to undergo transoral laser microsurgery from January 2002 until June 2014. Kaplan-Meier five-year analyses of local control, overall survival, disease-specific survival and laryngeal preservation were performed. Voice Handicap Index-10 scores and maximum phonation times were also recorded.RESULTS:
Twenty-one participants with a mean age of 66.8 years were enrolled. The mean follow up was 56.5 months. Kaplan-Meier 5-year survival analysis illustrated a local control rate of 82 per cent, overall survival of 88 per cent, disease-specific survival of 100 per cent, and laryngeal preservation of 100 per cent. The pre-operative Voice Handicap Index-10 score was 19.1 ± 9.47 (mean ± standard deviation (SD)) and the post-operative scores were 13.5 ± 9.29 at three months, 10.44 ± 9.70 at one year and 5.83 ± 4.91 at two years. The pre-operative maximum phonation time was 16.23 ± 5.46 seconds (mean ± SD) and the post-operative values were 14.44 ± 6.73 seconds at three months, 15.27 ± 5.71 seconds at one year and 14.33 ± 6.44 seconds at two years.CONCLUSION:
Transoral laser microsurgery yields relatively high rates of oncological control and acceptable voice outcomes, and thus shows utility as a primary treatment modality for T1b glottic cancer.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs du larynx
/
Thérapie laser
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Chirurgie endoscopique par orifice naturel
/
Microchirurgie
Type d'étude:
Evaluation_studies
/
Observational_studies
Limites:
Aged
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
J Laryngol Otol
Sujet du journal:
OTORRINOLARINGOLOGIA
Année:
2017
Type de document:
Article
Pays d'affiliation:
Canada