Inhibitors of Protein Tyrosine Phosphatase 1B from Marine Natural Products.
Chem Biodivers
; 14(7)2017 Jul.
Article
de En
| MEDLINE
| ID: mdl-28261970
ABSTRACT
The ocean is a capacious area with the most abundant biological resources on the earth. The particularity of the marine ecological environment (high pressure, high salt, and hypoxia) makes the marine species survival competition fiercely, forcing many marine organisms in the process of life to produce a great deal of secondary metabolites with special structures and biological activities. In this article, 118 natural products which were isolated from four kinds of marine organisms, sponges, algae, soft corals and fungus, showing PTP1B inhibitory activity were summarized from 2010 to 2016, which may become the leading compounds towards treating Diabetes mellitus (DM). What's more, we briefly summarized the structure-activity relationship of PTP1B inhibitors.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protein Tyrosine Phosphatase, Non-Receptor Type 1
/
Organismes aquatiques
Limites:
Animals
/
Humans
Langue:
En
Journal:
Chem Biodivers
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2017
Type de document:
Article