Bioanalysis of Pseudomonas aeruginosa alkyl quinolone signalling molecules in infected mouse tissue using LC-MS/MS; and its application to a pharmacodynamic evaluation of MvfR inhibition.

Turnpenny, Paul; Padfield, Anthony; Barton, Patrick; Teague, Joanne; Rahme, Laurence G; Pucci, Michael J; Zahler, Robert; Rubio, Aileen

Turnpenny, Paul; Padfield, Anthony; Barton, Patrick; Teague, Joanne; Rahme, Laurence G; Pucci, Michael J; Zahler, Robert; Rubio, Aileen.

Affiliation

Turnpenny P; Evotec, Drug Metabolism and Pharmacokinetics Department, Abingdon, Oxon, United Kingdom. Electronic address: paul.turnpenny@evotec.com.
Padfield A; Evotec, Drug Metabolism and Pharmacokinetics Department, Abingdon, Oxon, United Kingdom.
Barton P; Evotec, Drug Metabolism and Pharmacokinetics Department, Abingdon, Oxon, United Kingdom.
Teague J; Evotec, Anti-infective Research Unit, Manchester, United Kingdom.
Rahme LG; Department of Surgery, Massachusetts General Hospital, Boston, MA, United States; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, United States; Shriners Hospitals for Children, Boston, MA, United States.
Pucci MJ; Spero Therapeutics, Cambridge, MA, United States.
Zahler R; Spero Therapeutics, Cambridge, MA, United States.
Rubio A; Spero Therapeutics, Cambridge, MA, United States.

J Pharm Biomed Anal ; 139: 44-53, 2017 May 30.

Article de En | MEDLINE | ID: mdl-28273650

Sujet(s)
Mots clés

Alkyl-quinolone; Bioanalysis; LCMS/MS; Pseudomonas aeruginosa

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pseudomonas aeruginosa / Infections à Pseudomonas / 4-Quinolones / Spectrométrie de masse en tandem / Détection du quorum Limites: Animals / Humans Langue: En Journal: J Pharm Biomed Anal Année: 2017 Type de document: Article Pays de publication: Royaume-Uni

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