Role of Atypical Protein Kinases in Maintenance of Long-Term Memory and Synaptic Plasticity.
Biochemistry (Mosc)
; 82(3): 243-256, 2017 Mar.
Article
de En
| MEDLINE
| ID: mdl-28320265
ABSTRACT
Investigation of biochemical mechanisms underlying the long-term storage of information in nervous system is one of main problems of modern neurobiology. As a molecular basis of long-term memory, long-term changes in kinase activities, increase in the level and changes in the subunit composition of receptors in synaptic membranes, local activity of prion-like proteins, and epigenetic modifications of chromatin have been proposed. Perhaps a combination of all or of some of these factors underlies the storage of long-term memory in the brain. Many recent studies have shown an exclusively important role of atypical protein kinases (PKCζ, PKMζ, and PKCι/λ) in processes of learning, consolidation and maintenance of memory. The present review is devoted to consideration of mechanisms of transcriptional and translational control of atypical protein kinases and their roles in induction and maintenance of long-term synaptic plasticity and memory in vertebrates and invertebrates.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protein kinases
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Mémoire à long terme
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Apprentissage
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Protéines de tissu nerveux
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Plasticité neuronale
Limites:
Animals
/
Humans
Langue:
En
Journal:
Biochemistry (Mosc)
Année:
2017
Type de document:
Article
Pays d'affiliation:
Russie