In Vitro Intrinsic Permeability: A Transporter-Independent Measure of Caco-2 Cell Permeability in Drug Design and Development.

Fredlund, Linda; Winiwarter, Susanne; Hilgendorf, Constanze

Fredlund, Linda; Winiwarter, Susanne; Hilgendorf, Constanze.

Affiliation

Fredlund L; Molecular Screening and Profiling, Discovery Sciences, Predictive Compound ADME and Safety, Discovery Safety, Drug Safety and Metabolism, and §ADME and Biotransformation, DMPK Cardiovascular and Metabolic Diseases, Innovative Medicines Biotech Unit, AstraZeneca R&D Gothenburg , Mölndal 431 83, Sweden.
Winiwarter S; Molecular Screening and Profiling, Discovery Sciences, Predictive Compound ADME and Safety, Discovery Safety, Drug Safety and Metabolism, and §ADME and Biotransformation, DMPK Cardiovascular and Metabolic Diseases, Innovative Medicines Biotech Unit, AstraZeneca R&D Gothenburg , Mölndal 431 83, Sweden.
Hilgendorf C; Molecular Screening and Profiling, Discovery Sciences, Predictive Compound ADME and Safety, Discovery Safety, Drug Safety and Metabolism, and §ADME and Biotransformation, DMPK Cardiovascular and Metabolic Diseases, Innovative Medicines Biotech Unit, AstraZeneca R&D Gothenburg , Mölndal 431 83, Sweden.

Mol Pharm ; 14(5): 1601-1609, 2017 05 01.

Article de En | MEDLINE | ID: mdl-28329446

Sujet(s)
Mots clés

Caco-2; active transport; drug discovery; in silico modeling; in vitro−in vivo correlation; intestinal absorption; intrinsic permeability; passive diffusion

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Conception de médicament Type d'étude: Prognostic_studies / Risk_factors_studies Limites: Humans Langue: En Journal: Mol Pharm Sujet du journal: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Année: 2017 Type de document: Article Pays d'affiliation: Suède Pays de publication: États-Unis d'Amérique

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