Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.

Ward, Richard A; Bethel, Paul; Cook, Calum; Davies, Emma; Debreczeni, Judit E; Fairley, Gary; Feron, Lyman; Flemington, Vikki; Graham, Mark A; Greenwood, Ryan; Griffin, Nicola; Hanson, Lyndsey; Hopcroft, Philip; Howard, Tina D; Hudson, Julian; James, Michael; Jones, Clifford D; Jones, Christopher R; Lamont, Scott; Lewis, Richard; Lindsay, Nicola; Roberts, Karen; Simpson, Iain; St-Gallay, Steve; Swallow, Steve; Tang, Jia; Tonge, Michael; Wang, Zhenhua; Zhai, Baochang

Ward, Richard A; Bethel, Paul; Cook, Calum; Davies, Emma; Debreczeni, Judit E; Fairley, Gary; Feron, Lyman; Flemington, Vikki; Graham, Mark A; Greenwood, Ryan; Griffin, Nicola; Hanson, Lyndsey; Hopcroft, Philip; Howard, Tina D; Hudson, Julian; James, Michael; Jones, Clifford D; Jones, Christopher R; Lamont, Scott; Lewis, Richard; Lindsay, Nicola; Roberts, Karen; Simpson, Iain; St-Gallay, Steve; Swallow, Steve; Tang, Jia; Tonge, Michael; Wang, Zhenhua; Zhai, Baochang.

Affiliation

Ward RA; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Bethel P; AstraZeneca , Charter Way, Macclesfield, SK10 2NA, U.K.
Cook C; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Davies E; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Debreczeni JE; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Fairley G; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Feron L; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Flemington V; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Graham MA; AstraZeneca , Charter Way, Macclesfield, SK10 2NA, U.K.
Greenwood R; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Griffin N; AstraZeneca , Alderley Park, Macclesfield SK10 4TG, U.K.
Hanson L; AstraZeneca , Alderley Park, Macclesfield SK10 4TG, U.K.
Hopcroft P; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Howard TD; AstraZeneca , Alderley Park, Macclesfield SK10 4TG, U.K.
Hudson J; AstraZeneca , Alderley Park, Macclesfield SK10 4TG, U.K.
James M; AstraZeneca , Alderley Park, Macclesfield SK10 4TG, U.K.
Jones CD; AstraZeneca , Alderley Park, Macclesfield SK10 4TG, U.K.
Jones CR; AstraZeneca , Alderley Park, Macclesfield SK10 4TG, U.K.
Lamont S; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Lewis R; AstraZeneca , Charter Way, Macclesfield, SK10 2NA, U.K.
Lindsay N; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Roberts K; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Simpson I; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
St-Gallay S; AstraZeneca , Alderley Park, Macclesfield SK10 4TG, U.K.
Swallow S; AstraZeneca , Charter Way, Macclesfield, SK10 2NA, U.K.
Tang J; Pharmaron Beijing Co., Ltd. , 6 Taihe Road BDA, Beijing, 100176, P.R. China.
Tonge M; IMED Oncology and Discovery Sciences, AstraZeneca , Darwin Building, and AstraZeneca, Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Wang Z; Pharmaron Beijing Co., Ltd. , 6 Taihe Road BDA, Beijing, 100176, P.R. China.
Zhai B; Pharmaron Beijing Co., Ltd. , 6 Taihe Road BDA, Beijing, 100176, P.R. China.

J Med Chem ; 60(8): 3438-3450, 2017 04 27.

Article de En | MEDLINE | ID: mdl-28376306

Sujet(s)

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Système de signalisation des MAP kinases / Inhibiteurs de protéines kinases Limites: Animals / Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2017 Type de document: Article Pays d'affiliation: Royaume-Uni

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google