Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKC&#945;, PKCÎµ, and RasGRP.

Elhalem, Eleonora; Donadío, Lucía Gandolfi; Zhou, Xiaoling; Lewin, Nancy E; Garcia, Lia C; Lai, Christopher C; Kelley, James A; Peach, Megan L; Blumberg, Peter M; Comin, María J

Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCÎµ, and RasGRP.

Elhalem, Eleonora; Donadío, Lucía Gandolfi; Zhou, Xiaoling; Lewin, Nancy E; Garcia, Lia C; Lai, Christopher C; Kelley, James A; Peach, Megan L; Blumberg, Peter M; Comin, María J.

Affiliation

Elhalem E; Laboratory of Organic Synthesis, Center of Research and Development in Chemistry, National Institute of Industrial Technology, Buenos Aires, Argentina.
Donadío LG; Laboratory of Organic Synthesis, Center of Research and Development in Chemistry, National Institute of Industrial Technology, Buenos Aires, Argentina.
Zhou X; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Lewin NE; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Garcia LC; Laboratory of Organic Synthesis, Center of Research and Development in Chemistry, National Institute of Industrial Technology, Buenos Aires, Argentina.
Lai CC; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA.
Kelley JA; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA.
Peach ML; Basic Science Program, Leidos Biomedical Research Inc., Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702, USA.
Blumberg PM; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Comin MJ; Laboratory of Organic Synthesis, Center of Research and Development in Chemistry, National Institute of Industrial Technology, Buenos Aires, Argentina. Electronic address: jcomin@inti.gob.ar.

Bioorg Med Chem ; 25(12): 2971-2980, 2017 06 15.

Article de En | MEDLINE | ID: mdl-28392275

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Facteurs d'échange de nucléotides guanyliques / Protéines de liaison à l'ADN / Protein kinase C-alpha / Protein kinase C-epsilon / Indoles / Lactones Limites: Humans Langue: En Journal: Bioorg Med Chem Sujet du journal: BIOQUIMICA / QUIMICA Année: 2017 Type de document: Article Pays d'affiliation: Argentine Pays de publication: Royaume-Uni

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